Subinhibitory concentrations of penicillin increase the mutation rate to optochin resistance in Streptococcus pneumoniae
نویسندگان
چکیده
منابع مشابه
Subinhibitory concentrations of penicillin increase the mutation rate to optochin resistance in Streptococcus pneumoniae.
OBJECTIVES The aim of this work was to study the effect of subinhibitory concentrations of penicillin, chloramphenicol and erythromycin on the mutation rate of Streptococcus pneumoniae. METHODS The mutation rate to rifampicin and optochin resistance was estimated using fluctuation analysis in three capsulated S. pneumoniae strains, cultured both with and without different subinhibitory antibi...
متن کاملOptochin-resistant Streptococcus pneumoniae.
Streptococcus pneumoniae (pneumococcus) remains a major cause of mortality and morbidity at the extremes of age. With increasing antibiotic resistance, its accurate early identification is important for initial management [1]. Its identification in clinical laboratories relies on colony morphology, α-haemolysis on blood agar, and optochin susceptibility. The bile solubility test, although simpl...
متن کاملSelection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations.
OBJECTIVES Does exposure to subinhibitory concentrations of quinolones favour overexpression of efflux pumps or selection of target site mutations? METHODS ATCC 49,619 (fully susceptible) and SP32 (clinical isolate with PmrA-mediated efflux and mutation in ParE) were exposed for 24 h in broth to ciprofloxacin, levofloxacin, moxifloxacin or garenoxacin at concentrations of 0.5x the MIC, with d...
متن کاملEmergence of Optochin Resistance among Streptococcus pneumoniae in Japan
The optochin susceptibility test is a key method for differentiating Streptococcus pneumoniae from other -hemolytic streptococci; however, optochin-resistant (Opt) S. pneumoniae have been reported in the last two decades. In this study, we investigated the isolation frequency of Opt S. pneumoniae in the North Kyushu area of Japan, and biochemically and genetically characterized Opt S. pneumoni...
متن کاملEffect of subinhibitory concentrations of antibiotics on mutation frequency in Streptococcus pneumoniae.
OBJECTIVES To investigate the effect of subinhibitory concentrations of ciprofloxacin, streptomycin, trimethoprim, ampicillin and erythromycin on mutation frequency in Streptococcus pneumoniae. METHODS Frequency of mutation to rifampicin resistance was determined in three clinical isolates grown with or without antibiotic treatment. dinB was analysed using PCR and DNA sequence determination. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2008
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dkn322